4/11/2023 0 Comments Questasim 10.0b free downloadThe hardware architecture Synaptic Neuronal Circuit, SyNC, is a novel GPU accelerator or neural net, that extends discovery by acting as a biologically relevant realistic neuron synapse in real time. Here we generate a computational model referred to as ASD interrogator (ASDint) and corresponding hardware to enable in silicon analysis of multiple ASD mechanisms affecting glutamatergic neuron synapses. The hippocampus is implicated in autism spectrum disorders (ASD) and within this region glutamatergic neurons constitute 90% of the neurons integral to the functioning of neuronal networks. By co-development of algorithms alongside hardware, real time analysis metrics can be co-prioritized along with biological complexity. Such models should also evaluate disruptions to synaptic function by multiple mechanisms. To understand the complexity of information processing at synaptic networks will rely in part on effective computational models. Synaptic function and experience-dependent plasticity across multiple synapses are dependent on the types of neurons interacting as well as the intricate mechanisms that operate at the molecular level of the synapse.
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